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Anonymous (2001) Antimicrobial prophylaxis in surgery.Blanchet, B. 12-1 Introduction. The situation with Class II matching is less clear-cut. 4 Chapter 17 The Innate Immune System Fundamental Immunology Chapter 17 Ruslan Medzhitov The Innate Immune System INTRODUCTION INNATE IMMUNE RECOGNITION THE RECEPTORS OF THE INNATE IMMUNE SYSTEM THE CELLS OF THE INNATE IMMUNE SYSTEM THE EFFECTOR MECHANISMS OF THE INNATE IMMUNE SYSTEM CONTROL OF ADAPTIVE IMMUNITY BY THE INNATE IMMUNE SYSTEM Strategies of Innate Immune Recognition: Microbial Non-self and Missing Self Targets of Innate Immune Recognition Toll-like Receptors Phagocytic Receptors Secreted Pattern-Recognition Molecules Intracellular Recognition Systems Macrophages Neutrophils Mast Cells Eosinophils Dendritic Cells Surface Epithelium Lysozyme Chitinases Phospholipase A2 BPI Defensins Cathelicidins Serprocedins Lactoferrin, NRAMP, and Calprotectin Phagocyte Oxidase, Myeloperoxidase, and Nitric Oxide Synthase The Antiviral Effector Mechanisms of the Innate Immune System CONCLUSIONS ACKNOWLEDGMENTS REFERENCES INTRODUCTION Host defense against microbial infection is mediated by a variety of mechanisms that fall into two categories: innate and adaptive (or acquired).
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