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Tetrahydrofolic Acid and Other Pterin Coenzymes 811 H HA HR H CH2 N NH H O H199 HO N NO N229 C O HaHN HN O PO dUMP OH AH O H SEnz B H R O SEnz HO Methylene-THF HR HB N O b A CH2 N NH HN CH2NNHcHN H SEnz O N H O N SEnz HRA AH H d OO CH2 HN SEnz NH e CH3 N SEnz HN Non directional options trading home study course download O N H2 folate f O HN ON A:, AH, B:; catalytic basic or acidic groups O CH3 SEnz Thymidylate (dTMP) Figure 15-21 Probable mechanism of action of thymidylate synthase.

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